Somatostatin is a cyclic peptide that is remarkably well conserved in evolution. Somatostatin analogs are used for treatment of tumors secreting vasoactive intestinal peptide, carcinoid tumors, glucagonomas and various pituitary adenomas. Neuroendocrine gastro-entero-pancreatic tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow up K Oberg and others Vol 15, Pages 966-973. One‐third of the studies used intravenous somatostatin or octreotide, and the rest used a somewhat narrower range of subcutaneous dosages of octreotide. It is also used to treat acromegaly (a condition in where there is oversecretion of growth hormone in an adult). In 1990, Ulibarri et al. Somatostatin can reduce abdominal blood flow therefore somatostatin analogs can be used to reduce bleeding from esophageal varices. A disulfide bond between cysteine residues maintains the cyclic structure. Chemically altered equivalents of somatostatin are used as a medical therapy to control too much hormone secretion in patients with acromegaly and other endocrine conditions, and to treat some gastrointestinal diseases and a variety of tumours. Somatostatin and its synthetic analogs are used clinically to treat a variety of neoplasms. It is also used to treat gigantism and acromegaly, due to its ability to inhibit the secretion of growth hormone. Lamberts SW, Krenning EP, Klijn JG, Reubi JC. Pharmacological uses of somatostatin. Pharmacologic Uses of Somatostatin. Somatostatin and its synthetic analogs are used clinically to treat a variety of neoplasms. Injection of somatostatin into the brain of rodents leads to such things as increased arousal and decreased sleep, and impairment of some motor responses. Somatostatin analogs such as octreotide and lanreotide, which present a high affinity for sst(2), are in current clinical use to alleviate symptoms in patients with endocrine tumors, and radiolabeled somatostatin analogs have been developed for diagnosis and radiotherapy. were the first to describe the successful use of somatostatin in an adult patient with chyle leak due to injury to thoracic duct following laryngectomy and lymphadenectomy. Despite universal use of somatostatin, the cellular and biochemical mechanisms of its effects in portal hypertension are relatively poorly studied and remain incompletely understood. Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system K Oberg and others Annals of Oncology, 2004. Somatostatin(Eklivan) generic is a peptide hormone, prescribed for gastrointestinal hemorrhage. The only trial available on the subject was an animal study. Somatostatin-14 is identical to the carboxyl terminal 14 amino acids of somatostatin-28. The clinical use of somatostatin analogues in the treatment of cancer. The biological activity of S-14 and S-28 resides in the cyclic region of the mature peptide.