Saeedi, M., Morteza-Semnani, K., and Ghoreishi, M. R. The treatment of atopic dermatitis with licorice gel. View abstract. Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora. Melzer J, Rosch W, Reichling J, et al. Digestion 2004;69:45-52. Pathogenetic considerations and presentation of a clinical case]. View abstract. J Ethnopharmacol 2002;81:101-4.. View abstract. View abstract. View abstract. In a 30-day study in 50 adults with indigestion, taking a 75-mg licorice . Okubo T, Nagai F, Seto T, et al. Acta Endocrinol (Buchar) 2020;16(4):508-510. Wu, T. H., Chiu, T. Y., Tsai, J. S., Chen, C. Y., Chen, L. C., and Yang, L. L. Effectiveness of Taiwanese traditional herbal diet for pain management in terminal cancer patients. Chamberlain, J. J. and Abolnik, I. Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information. Awad N, Makar G, Burroughs V, Ravi P, Burroughs SR. Licorice-induced apparent mineralocorticoid excess causing persistent hypertension and hypokalemia. View abstract. Goultschin, J., Palmon, S., Shapira, L., Brayer, L., and Gedalia, I. Licorice-induced hypermineralocorticoidism. Guo TL, Zhou XW. Food Chem Toxicol 1993;31:303-12. Effects of the Japanese herbal medicine "Sho-saiko-to" (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C. Hepatology 1997;25(6):1390-1397. View abstract. Can J Cardiol 2009;25(10):e357-e358. Rosenblat, M. and Aviram, M. Paraoxonases role in the prevention of cardiovascular diseases. View abstract. N Engl J Med 1990;322:850. An open study of 100 women with uterine fibroids showed that peony reduced the size of . Eur Neurol 1992;32(1):44-51. Taking licorice with paclitaxel might decrease the effects of paclitaxel. However, taking too much licorice root may cause side effects. Liang, R. N., Liu, J., and Lu, J. Journal of Clinical Therapeutics Medicine. 1991;78(1-2):1-6. Apparantly it's the one most important thing that shouldn't mix with Prednisolone and it makes withdrawal symptoms much worse. Eur J Obstet Gynecol.Reprod Biol 2007;131(1):61-67. View abstract. Licorice root is aromatic and is used as a flavoring agent in tea and other beverages. Phytother Res. Read about Peony uses, side effects, health benefits, interactions, dose, warnings, and precautions. Beretta-Piccoli, C., Salvade, G., Crivelli, P. L., and Weidmann, P. Body-sodium and blood volume in a patient with licorice-induced hypertension. [Clinical observations on the treatment of the gestational hypertension syndrome with Angelica and Paeonia powder]. Gut 1973;14(9):711-715. View abstract. J Nutr 2001;131:1471-8. 2004;4(3):377-386. Clin Pharmacol Ther 1996;59:62-71. View abstract. Z Gastroenterol 2001;39(7):511-7. Licorice might change how these pumps work and change how much medication stays in the body. View abstract. Warfarin is used to slow blood clotting. View abstract. View abstract. . Li C, Wang ZB. View abstract. Glycyrrhizin-Induced Pseudohyperaldosteronism: A Case Report. Pak J Med Sci 2022;38(1):271-275. Phytother Res 1988;2(3):140-145. G Ital Dermatol Venereol 2010;145(6):789-792. Ngan LT, Moon JK, Shibamoto T, Ahn YJ. Licorice that has the active ingredient of glycyrrhiza can have serious side effects. I like herbal and fuit teas and a particular favourite of mine contains liquorice. Peony might slow blood clotting. Let's take a look at the forms, uses, and side effects of . Dai DW, Singh I, Hershman JM. Evaluation of contextual and demographic factors on licorice effects on reducing hot flashes in postmenopause women. PEONY: Overview, Uses, Side Effects, Precautions, Interactions - WebMD Madisch A, Holtmann G, Mayr G, et al. Phytother Res. Steroids 2004;69(11-12):763-766. Life Sci 9-27-2002;71(19):2267-2277. J Agric Food Chem 6-13-2007;55(12):4691-4697. It contains kojic acid, witch hazel, and licorice extracts that reduce melanin production and exfoliate . This Halloween, you'll want to stay vigilant about the candy . View abstract. View abstract. Do White Peony and Licorice Help with Hirsutism Symptoms? Contact Dermatitis 2008;59(1):52. Licorice is an herb that grows in parts of Europe and Asia. Prieto JM, Recio MC, Giner RM, et al. Pharmazie 2010;65(8):624-8. O'Connell K, Kinsella J, McMahon C, Holian J, O'Riordan S. Posterior reversible encephalopathy syndrome (PRES) associated with liquorice consumption. van Uum SH. View abstract. Grapefruit juice and its flavonoids inhibit 11 beta-hydroxysteroid dehydrogenase. View abstract. View abstract. 1991;4(2):166-173. Bai, Y. S., Zhou, C. Y., and Wang, J. Q. Wang H, Wei W, Wang NP, et al. Int J Dermatol 1999;38:387-92 . Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Yamashiki, M., Nishimura, A., Suzuki, H., Sakaguchi, S., and Kosaka, Y. Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. [Comparison of pre- and post-treatmental hepatohistology with heavy dosage of Paeonia rubra on chronic active hepatitis caused liver fibrosis]. View abstract. View abstract. Med Princ Pract 2010;19(6):485-489. Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses. Sontia B, Mooney J, Gaudet L, Touyz RM. Man dies after eating bags of black licorice every day Liang Xiao, Wang YZ, Jing Liu, et al. View abstract. Xie HJ, Yasar U, Sandberg M, Rane A. Paeoniae Radix, a traditional Chinese medicine, and CYP2C9 activity. Altern Med Rev 1999;4(3):178-188. Riv Patol Nerv Ment 1983;104(4):179-183. View abstract. Here are a few of them: . Further studies on the mechanism of the mineralocorticoid action of licorice in humans. View abstract. Phytother Res 2008;22(2):141-148. Aliment Pharmacol Ther 2004;20:1279-87. Gao, X., Wang, W., Wei, S., and Li, W. [Review of pharmacological effects of Glycyrrhiza radix and its bioactive compounds]. Bocker, D. and Breithardt, G. [Induction of arrhythmia by licorice abuse]. The Benefits of Licorice Root for Women - Dr. Jolene Brighten View abstract. Yamamoto, T., Hatanaka, M., Matsuda, J., Kadoya, H., Takahashi, A., Namba, T., Takeji, M., and Yamauchi, A. Some medications are changed and broken down by the liver. View abstract. Since the content of glycyrrhizin is either decreased or removed from the DGL licorice supplement, its positive effects on PCOS may also be reduced. The immediate effect of Shakuyaku-kanzo-to, traditional Japanese herbal medicine, for muscular cramps during maintenance hemodialysis. Effect of shakuyaku-kanzoh-toh, a prescription composed of shakuyaku (Paeoniae Radix) and kanzoh (Glycyrrhizae Radix) on guinea pig ileum. Phytother Res 2009;23(2):246-250. Effects of Paeonia lactiflora root extracts on the secretions of monocyte chemotactic protein-1 and -3 in human nasal fibroblasts. Gallacher SD, Tsokolas G, Dimitropoulos I. Liquorice-induced apparent mineralocorticoid excess presenting in the emergency department. 2017 Sep;31(9):1330-1340. Isaia, G. C., Pellissetto, C., Ravazzoli, M., and Tamone, C. Acute adrenal crisis and hypercalcemia in a patient assuming high liquorice doses. View abstract. Select a condition to view a list of vitamins. Saw palmetto. Kase Y, Saitoh K, Ishige A, et al. Learn more about Peony health benefits, uses, side effects, effectiveness, safety, precautions, and warnings. Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: Aspirin; Clopidogrel; Warfarin; St. John's wort. Comparative Study of the Effect of Licorice Muco-adhesive Film on Radiotherapy Induced Oral Mucositis, A Randomized Controlled Clinical Trial. Peony for Women's Health and Beyond View abstract. View abstract. . Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis. Biomed.Chromatogr. Thom E and Wollan T. A controlled clinical study of kanjang mixture in the treatment of uncomplicated upper respiratory tract infections. Kumada T, et al. View abstract. Lozenge-induced hypermineralcorticoid state--a unique case of licorice lozenges resulting in hypertension and hypokalemia. 2009;14(1):64-65. Chatterjee, N., Domoto-Reilly, K., Fecci, P. E., Schwamm, L. H., and Singhal, A. Zhong Xi Yi Jie He Za Zhi 1990;10:101-2, 70. . [13] A study in Japan compared the use of a . Peters, M. C., Tallman, J. Kang, D. G., Moon, M. K., Choi, D. H., Lee, J. K., Kwon, T. O., and Lee, H. S. Vasodilatory and anti-inflammatory effects of the 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) via a nitric oxide-cGMP pathway. 1998;111(7):585-587. 2017 Apr 1;27(2):150-154. doi: 10.1684/ejd.2016.2946. Grebeniuk, V. N., Mannanov, A. M., Korsun, V. F., and Vinogradova, A. I. 83rd Annual Meeting of the Endocrine Society, June 20-23 2001;abstract P1-573. He X, Xing D, Ding Y, et al. Rare case of black licorice poisoning kills man in Massachusetts The combination alters the Luteinising Hormone vs Follicle Stimulating Hormone ratio that is abnormal in PCOS. No negative side effects. Antimicrobial isoflavanoids and related substances from Glycyrrhiza glabra L. var. Effect of Japanese Angelica root and peony root on uterine contraction in the rabbit in situ. Anonymous. Medicinal uses of licorice through the millennia: the good and plenty of it. The dogs treated with the herbal mixture saw a 37.5 percent improvement . Yamada, K., Kanba, S., Yagi, G., and Asai, M. Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. Side effects, toxicity, and interactions. [Effect of Paeonia obovata 801 on metabolism of thromboxane B2 and arachidonic acid and on platelet aggregation in patients with coronary heart disease and cerebral thrombosis]. Am J Chin Med 2003;31:445-53. . List of herbs with known adverse effects - Wikipedia 30. View abstract. View abstract. 2000;20(3):173-175. Nippon Rinsho 1994;52:1817-22. What are the side-effects of taking liquorice? View abstract. Zhong Xi Yi Jie He Za Zhi 1986;6:714-6, 707. Asian Medical Journal 1984;26(7):423-438. Edelman ER, Butala NM, Avery LL, Lundquist AL, Dighe AS. Zheng, A. and Moritani, T. Effect of the combination of ginseng, oriental bezoar and glycyrrhiza on autonomic nervous activity and immune system under mental arithmetic stress. Loop diuretics can also decrease potassium levels. Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial. CJEM 2009;11(1):94-96. Clin Rheumatol. Abe K, Higurashi T, Takahashi M, et al. View abstract. Title 21. Mechanisms by which Hange-shashin-to reduces prostaglandin E2 levels. View abstract. N Engl J Med 1991;325:1223-7. View abstract. View abstract. Nabeshima, S., Kashiwagi, K., Ajisaka, K., Masui, S., Takeoka, H., Ikematsu, H., and Kashiwagi, S. A randomized, controlled trial comparing traditional herbal medicine and neuraminidase inhibitors in the treatment of seasonal influenza. View abstract. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. View abstract. J Gastroenterol 1996;31(5):691-695. OTHER NAME(S): Bai Shao, Chi Shao, Chinese Peony, Common Peony, C. Peony (Paeonia lactiflora) is an herb. The roots are commonly used in Traditional Chinese Medicine (TCM) for many purposes. B., and Zhang, Z. J. The Potential Benefits and Side Effects of the White Peony Root. J Clin Psychopharmacol 1997;17(3):234-235. View abstract. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. Kinoshita T, Maruyama K, Yamamoto N, Saito I. Black licorice can have serious side effects when eaten in large amounts. Wen Y, Tang Y, Li M, Lai Y. Kinoshita, H., Okabayashi, M., Kaneko, M., Yasuda, M., Abe, K., Machida, A., Ohkubo, T., Kamata, T., and Yakushiji, F. Shakuyaku-kanzo-to induces pseudoaldosteronism characterized by hypokalemia, rhabdomyolysis, metabolic alkalosis with respiratory compensation, and increased urinary cortisol levels. Licorice reduces body fat mass in obese men and women. View abstract. Licorice might increase how quickly midazolam is broken down by the body. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Evid Based Complement Alternat Med. Black Licorice: Dangerous Candy - WebMD Bian, X., Xu, Y., Zhu, L., Gao, P., Liu, X., Liu, S., Qian, M., Gai, M., Yang, J., and Wu, Y. View abstract. Medically reviewed by Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT By Kirsten Nunez on October 16, 2020. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. Am J Chin Med 2003;31:445-53. . View abstract. Licorice might increase how quickly the body breaks down paclitaxel. Immunology 1997;90(1):115-120. Asia Pac.J Clin Nutr 2008;17(1):17-22. View abstract. Tu, J. H., He, Y. J., Chen, Y., Fan, L., Zhang, W., Tan, Z. R., Huang, Y. F., Guo, D., Hu, D. L., Wang, D., and Hong-Hao Zhou. Peony might block chemicals that can cause pain and swelling . View abstract. Armanini D, Bonanni G, Mattarello MJ, et al. The 1:1 of peony and licorice group can significantly reduced the ureteral smooth muscle tension and Christina Loosestrife herb can increase the u reteral tension, but the amount is too large, the mechanism may be related with the diuretic row stone. The glycyrrhizin and glycyrrhetic acid constituents of licorice have significant anti-androgen effects, 32-34 which may be helpful in reducing androgenic symptoms in women with PCOS. Ed. Lee, C. H., Park, S. W., Kim, Y. S., Kang, S. S., Kim, J. Minerva Med 2008;99(1):91-94. It's not suggested to take St. John's wort if you take blood thinners. View abstract. Because of its beneficial effects, the licorice root has been dubbed the "Medicinal plant of 2012." Now scientists have discovered that licorice root from the papilionaceae or leguminous family . View abstract. View abstract. Nephrologie 1993;14(4):177-181. Caradonna, P., Gentiloni, N., Servidei, S., Perrone, G. A., Greco, A. V., and Russo, M. A. Eur J Clin Pharmacol 2010;66(8):805-810. Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism. Liu X, Li X, Li X, et al. Phytotherapy Research 1997;11:207-210. van Gelderen, C. E., Bijlsma, J. Eyi, E. G., Engin-Ustun, Y., Kaba, M., and Mollamahmutoglu, L. Ankaferd blood stopper in episiotomy repair. Fan ZJ, Liu JM, Li XX, et al. Zhonghua Yi Xue Za Zhi 1983;63:477-81. Z., Zhang, Y. Guo, T. L. and Zhou, X. W. [Clinical observations on the treatment of the gestational hypertension syndrome with Angelica and Paeonia powder]. Therapeutic Research Faculty 2020. Dobbins, K. R. and Saul, R. F. Transient visual loss after licorice ingestion. J Clin Psychopharmacol 2008;28(3):264-370. Nihon Jinzo Gakkai Shi 2010;52(1):80-85. Endocrinol Jpn 1991;38(2):167-174. Armanini, D., Castello, R., Scaroni, C., Bonanni, G., Faccini, G., Pellati, D., Bertoldo, A., Fiore, C., and Moghetti, P. Treatment of polycystic ovary syndrome with spironolactone plus licorice. 2016 Nov;48(11):1873-1880. doi: 10.1007/s11255-016-1345-5. Farese RV Jr, Biglieri EG, Shackleton CH, et al. Werner, S., Brismar, K., and Olsson, S. Hyperprolactinaemia and liquorice. Brush, J., Mendenhall, E., Guggenheim, A., Chan, T., Connelly, E., Soumyanath, A., Buresh, R., Barrett, R., and Zwickey, H. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. Paeonia lactiflora : Peony is another popular anti-androgenic herb. Zhang XH, Lowe D, Giles P, et al. View abstract. . Treatment of duodenal ulcer with glycyrrhizinic-acid-reduced liquorice. B. and Tang, T. Q. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever. Phytother Res 2008;22:563-5. Hinoshita F, Ogura Y, Suzuki Y, et al. Gut 1978;19(9):779-782. Guo, D., Ye, G., and Guo, H. A new phenolic glycoside from Paeonia lactiflora. View abstract. Arase, Y., Ikeda, K., Murashima, N., Chayama, K., Tsubota, A., Koida, I., Suzuki, Y., Saitoh, S., Kobayashi, M., and Kumada, H. The long term efficacy of glycyrrhizin in chronic hepatitis C patients. J Contemp.Dent Pract. Doeker, B. M. and Andler, W. Liquorice, growth retardation and Addison's disease. Cisplatin is used to treat cancer. View abstract. Barrella, M., Lauria, G., Quatrale, R., and Paolino, E. Hypokaliemic rhabdomyolysis associated with liquorice ingestion: report of an atypical case. View abstract. Brasseur, A. and Ducobu, J. The benefits of licorice root can be enjoyed as a tea, supplement, tincture, or topical treatment, and even as candies. View abstract. American Herbal Products Association's Botanical Safety Handbook, Second Edition. Kuriyama A, Maeda H. Topical application of licorice for prevention of postoperative sore throat in adults: a systematic review and meta-analysis. View abstract. Cai Y, Yuan Q, Xu K, et al. A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers. View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. As I've all but cut out alcohol, I've tended to drink this tea before going to bed and sometimes during the day. Licorice might change how quickly the liver breaks down these medications. Feng ZT, Xu J, He GC, Cai SJ, Li J, Mei ZG. View abstract. Hussain RM. Phytomedicine 2003;10:271-85. Why Black Licorice Can Make Your Heart Skip - Cleveland Clinic J Clin Endocrinol Metab 1990;70(6):1637-1643. Yoon JY, Cha JM, Hong SS, et al. 2018;38(2):617-8. View abstract. Biol Pharm Bull. Allergic contact dermatitis to Glycyrrhiza inflata root extract in an anti-acne cosmetic product. Hataya Y, Oba A, Yamashita T, Komatsu Y. Hyponatremia in an elderly patient due to isolated hypoaldosteronism occurring after licorice withdrawal. Sigurjonsdottir, H. A., Manhem, K., Axelson, M., and Wallerstedt, S. Subjects with essential hypertension are more sensitive to the inhibition of 11 beta-HSD by liquorice. Benge E, Shah P, Yamaguchi L, Josef V. Trick or Treat? Motherwort, Peony, Dong Quai, Lady's Mantle, Licorice, and Rose, Fennel, Alfalfa. Hajiaghamohammadi, A. View abstract. View abstract. Am J Nephrol 2000;20:145-8. View abstract. View abstract. Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis. Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects. Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. View abstract. Life Sci 2-23-2001;68(14):1687-1694. Pfeifer BL, Pirani JF, Hamann SR, Klippel KF. Acharya SK, Dasarathy S, Tandon A, et al. View abstract. View abstract. View abstract. Effect of Shakuyaku-kanzo-to (Tsumura TJ-68) on muscle cramps accompanying cirrhosis in a placebo-controlled double-blind parallel study. Effect of glycyrrhizin-containing toothpaste on dental plaque reduction and gingival health in humans. Roussak NJ. J Clin Hypertens (Greenwich) 2008;10:153-7. 2020;2020:3727682. View abstract. (Doses up to 60 grams daily for up to 4 months have been used without reported adverse effects.) Therapeutic basis of glycyrrhizin on chronic hepatitis B. Antiviral Res 1996;30:171-7. Ann Clin Biochem 2007;44(Pt 4):397-399. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Hyodo T, Taira T, Kumakura M, et al. Corse, F. M., Galgani, S., Gasparini, C., Giacanelli, M., and Piazza, G. Acute hypokalemic myopathy due to chronic licorice ingestion: report of a case. J Ethnopharmacol 2021;275:114116. Wang H, Dong L, Qu F, et al. View abstract. The treatment of human cancer with agents prepared from bovine cartilage. Steroids 2005;70(8):538-542.