does blood type affect covid vaccine side effects does blood type affect covid vaccine side effects

Common side effects included: tenderness at the injection site for 73% of participants. But how? No change is recommended in COVID-19 vaccination practice. Sleep expert Dr. Michael Breus strongly advises that getting a good nights sleep is essential before you go in for the vaccine in order to build a healthy antibody response.7. These usually last from a few hours to a few days after vaccination. A side effect or reaction isn't necessarily all bad, by the way; it may indicate that the body is building protection against the virus. Researchers found no link between blood type and COVID-19 risk, adding that more research was needed on the topic. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. Enjoying our content? Those symptoms are similar in all vaccines, but in the two-dose vaccines, they are more common after the second shot. The sore arm can be either due to the trauma of the needle in the muscle, or local inflammation in the muscle probably because of the chemicals in the injection, said Prof Robert Read, head of clinical and experimental sciences within medicine at the University of Southampton and director of the National Institute of Health Researchs Southampton Biomedical Research Centre. One of these areas contains genes that determine blood type along with other genes that are known to be associated with immune function. In patients with severe disease, deposition of terminal complement and microthrombosis have been observed in the lung, skin, kidney, and heart.14 Recently, we demonstrated that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein leads to amplification of the alternative pathway of complement on cell surfaces through competition with complement factor H (CFH) for binding heparan sulfate.5 Thus, in vitro, the SARS-CoV-2 spike protein can convert an inactivator surface to an activator surface on nucleated cells. "People with type O blood may be more susceptible to norovirus," said infectious disease expert Amesh A. Adalja, MD, senior scholar at the Johns Hopkins Center for Health Security. Annex V As seen in patients 3 and 6, a proximal complement inhibitor, such as danicopan, may prevent breakthrough hemolysis precipitated by the vaccine; however, it is equally possible that the stronger immune response after the second vaccine dose was primarily responsible for the breakthrough hemolysis in patient 3. Prior to joining GH in 2019, Zee fostered a nutrition background as an editor at Cooking Light and is continually developing his grasp of holistic health through collaboration with leading academic experts and clinical care providers. But for young adults that equation, at least at present, is less clearcut. Your comment will be reviewed and published at the journal's discretion. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. The question of a possible relationship between blood type and disease risk has been a topic of active research since early in the pandemic. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal, or homeopathic supplement, or using any treatment for a health problem. Researchers think the clotting may be triggered by the high . Centers for Disease Control and Prevention, you didn't experience any side effects at all, better bolster your body's immune response, other better-for-you fluids to stay hydrated, Your Privacy Choices: Opt Out of Sale/Targeted Ads, Take over-the-counter medication like ibuprofen, acetaminophen, aspirin, and antihistamines as needed, Apply a cold compress or a wet washcloth over the injection site if experiencing redness or swelling, Exercise your arm after injection to mitigate discomfort. Blurred vision, nausea and vomiting, difficulty with speech, weakness, drowsiness or seizures New unexplained pin-prick bruising or bleeding Shortness of breath, chest pain, leg swelling or. Building E23 Patient 2 is a 45-year-old man with a 20-year history of PNH. The clots may also form in multiple places in the body, including in the lungs. Some research findings have suggested that people with blood types A and AB are more susceptible to contracting. These include soreness where the jab was. Chills,. But in each instance, these have appeared soon after widespread use of the vaccine began. Zee Krstic is a health editor for Good Housekeeping, where he covers health and nutrition news, decodes diet and fitness trends and reviews the best products in the wellness aisle. associate medical director of infection prevention at UCI Health and a professor at the University of California, Irvine, posits an analogy that this bivalent vaccine is like a riff on a standard brownie recipe: "You're going to have almost the same ingredients, and bake it for the same time at the same temperature but this time, instead of just chocolate chips, you add dark chocolate, too," she tells Good Housekeeping. You shouldnt panic if you have Type A blood, and you shouldnt feel complacent if youre Type O. But if you understand how vaccines work, you'll know that experiencing a side effect isn't a sign that something's gone wrong. Chills. They include: tenderness, swelling, and. The information in this story is accurate as of press time. Got a question about COVID-19? The data suggests that side-effects are more common among younger recipients. Of course, your blood type is not a risk factor over which you have any control. Headache. Dr. Susan R. Bailey, an allergist, immunologist and president of the American Medical Association, said side effects develop because your immune system is reacting to the vaccine. It may also offer a little more peace of mind if youre exposed or do get infected. The O- blood group did not appear protective against severe COVID-19 illness and death (aRR, 0.84; 95% CI, 0.64-1.07) compared with other blood groups. Uncommon side-effects include having swollen lymph nodes. Recent research is suggesting that your blood type may affect your risk of getting COVID-19 and could influence the severity of the disease. People may. The latest Omicron COVID-19 vaccine may lead to similar side effects caused by earlier versions, which include injection site pain, fatigue, fever and more. In addition to the lungs, blood clots, including those associated with COVID-19, can also harm: The nervous system. The other common side-effects the muscle aches, flu-like illness and fatigue are probably due to generalised activation of the immune system caused by the vaccine. The first hint of a possible relationship came in March, from researchers in China, who compared nearly 2,200 hospitalized COVID-19 patients to a control group of approximately 27,000 healthy individuals. However, they did not find strong evidence for a relationship between blood group and risk of intubation or death. Blood clots in the arteries leading to the brain can cause a stroke. Common Moderna COVID-19 Vaccine side effects may include: fever, chills; redness or a hardness and swelling where the shot was given; swelling or tenderness under your arm; nausea, vomiting; feeling tired; or. This "Covid arm" rash can be red, itchy, swollen, or painful. The online version of this article contains a data supplement. Side. "We do not expect [the public] to experience anything that would be out of the ordinary from our experience with the original vaccination.". The authors of the NEJM study hypothesize that different combinations of A and B antigens may change how the immune system produces infection-fighting antibodies or have some other, unknown effect on how the body responds to infection. Experts aren't expecting a dramatic shift in side effects triggered by new COVID-19 bivalent booster vaccines targeted toward Omicron spread. If you wish to read unlimited content, please log in or register below. According to Public Health England, most side-effects from two Covid vaccines - Pfizer/BioNTech and Oxford/AstraZeneca - are mild and short-lived. That evidence best comes from looking at the responses from older people and younger people because the evidence is that the vaccines are very effective right across the age range, but the side-effect profile is weighted towards younger people., How UK doctor linked rare blood-clotting to AstraZeneca Covid jab, Original reporting and incisive analysis, direct from the Guardian every morning. Search for other works by this author on: Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases. Is this true? And people with some blood disorders like sickle cell disease are resistant to malaria, added Dr. Adalja. Blood 2021; 137 (26): 36703673. fatigue for 50% of the participants. Briefly, type O-positive red blood cells from 1 patient with PNH and 1 control were collected. We call this the viral load. In large clinical trials, most side effects have been minor. Side effects of the coronavirus (COVID-19) vaccination Very common side effects in the first day or two include: having a painful, heavy feeling and tenderness in the arm where you had your injection feeling tired headache, aches and chills diarrhoea, nausea and vomiting mild flu-like symptoms "The other half is focused on the new sub-variants that have been causing nearly all the disease we've been seeing over the past few months.". Since the formulation of this particular round of bivalent booster vaccines was made in a very similar process to earlier options, experts aren't expecting any new subsets of potential side effects to present this fall. and T32 HL 007525 (G.F.G. Register for free and gain unlimited access to: - Clinical News, with personalized daily picks for you Diet is also key, and as you are probably well aware of by now if youve been following me a healthy microbiome is a must. Secondary outcome results indicated that type O blood group had an aRR of 0.87 (95% CI, 0.78-0.97) for severe COVID-19 illness and death versus all other blood groups and Rh- status had an aRR of 0.82 (95% CI, 0.68-0.96) compared to . "We are learning a lot about coronavirus infection and the impact it has on the heart and vascular system," says Dr. Anderson. Whether you know your blood type or not, its still necessary for your sake and the sake of those around you to follow public health precautions, such as handwashing, mask-wearing, physical distancing, and staying home to stay safe. Dont miss out on todays top content on Infectious Disease Advisor. In populations at high-risk for exposure, such as healthcare workers, essential workers, and people exposed to a known case of the disease, the O blood type had an even greater protective effect. When side effects occur, they typically last just a few days. Fatigue. The latest data on blood type is still preliminary. A Top Derm Explains, 35 of the Smartest Fast-Food Choices You Can Make, Easy Brain Exercises to Boost Your Memory, Why We Should All Be Eating More Buckwheat, COVID-19 Emergency Funding Is Coming to an End. That means getting vaccinated and boosted, social distancing, wearing a mask in public, and washing your hands regularly, among other things. Not necessarily. The relative protective effects of O, Rh-, and O- blood groups were greatest in patients younger than age 70. On the evening after his first dose of the Pfizer-BioNTech vaccine, he experienced fever, headache, myalgia, and severe fatigue, which lasted 6 days. The Centers for Disease Control and Prevention (CDC) lists risk factors that have been identified for developing severe COVID-19, and blood type does not appear. "This is a similar process that we go through with our annual influenza vaccination.". Hearst Magazine Media, Inc. All Rights Reserved. While it's always helpful to know your blood type, most people won't necessarily need to know that information. The second study (also from October 2020) from researchers in Canada looked at data from 95 patients who were severely ill with COVID-19. Blood types can also serve as receptors for viruses and bacteria, and that could be another factor, explained Dr. Russo, there may be some other, completely different component of type O blood that works to prevent infection. Americans are learning more about the new set of bivalent COVID-19 booster vaccines made by teams at Pfizer and Moderna after officials at the .css-1me6ynq{-webkit-text-decoration:underline;text-decoration:underline;text-decoration-thickness:0.0625rem;text-decoration-color:#125C68;text-underline-offset:0.25rem;color:#125C68;-webkit-transition:all 0.3s ease-in-out;transition:all 0.3s ease-in-out;}.css-1me6ynq:hover{color:#595959;text-decoration-color:#595959;}Food and Drug Administration (FDA) authorized its rollout earlier this month. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Deep, healing sleep, reducing stress, walking or other forms of gentle exercise, plus pampering yourself, are important for helping to create a robust immune system. Lexington, MA 02421. Even Mild COVID-19 Infections Increase Risk of Type 2 Diabetes, Research Shows, Journal of the American Medical Association, CDC guidelines to prevent the spread of COVID-19. Good Housekeeping participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites. should be listed as a very rare side-effect of the vaccine, adults under the age of 30 should be offered alternative Covid vaccines, under way into the Johnson & Johnson (J&J) Covid jab. According to Australian data collected on the influenza vaccine in 2020, only 5.5% of people reported any adverse event, with just 0.3% being serious enough to see a doctor about. If so, how can I get that information? Those two factors make up the eight most common blood types: A+, A-, B+, B-, O+, O-, AB+, and AB-. There have been multiple studies on blood types and COVID-19 risk. This work was supported by National Institutes of Health, National Heart, Lung, and Blood Institute grants R01 HL 133113 (R.A.B.) Perhaps having both anti-A and anti-B antibodies gives type O individuals the ability to minimize the disease. Side effects in adults >55 after Pfizer-BioNTech vaccine (second dose) Pain at injection site (66.1%) Fatigue (50.5%) Headache (39.0%) Muscle pain (28.7%) Chills (22.7%) Joint pain (18.9%) Fever (10.9%), diarrhea (8.3%) and vomiting (0.7%) were also reported. "There is no real benefit for the individual person," said Torben Barington, DMSc, a clinical professor of immunology at the University of Southern Denmark and co-author of the early Danish study. "There's a fairly decent amount of existing literature beyond SARS-CoV-2" that certain blood types can play a role in disease risk and severity, says Joel Ray, M.D., a clinician scientist and professor at St. Michael's . Association between ABO and Rh blood groups and SARS-CoV-2 infection or severe COVID-19 illness. Blood type O seems to have the lowest risk. What are the common side effects of the COVID-19 vaccine? Thanks for visiting Infectious Disease Advisor. If any of these side effects occur, they should go away in a few days. However, as the situation surrounding COVID-19 continues to evolve, it's possible that some data have changed since publication. Sherrill Brown, M.D., medical director of infection prevention for AltaMed Health Services, indicates that current side effect notices published by the FDA sourced data from both Pfizer and Moderna's separate clinical trials for the earlier BA. For the most up-to-date information on COVID-19, please visit online resources provided by the CDC, WHO, and your local public health department. MIT Medical People react differently after being vaccinated. While the UK has ordered 30m doses of the J&J jab, it has not yet been authorised for use by the MHRA. In fact, fewer than 57% of all Americans know their blood type, according to a 2019 survey from Quest Diagnostics. designed and performed research; J.Y., B.A.Y.C., E.M.B., and S.C. interpreted results and edited the paper; R.A.B. This variant is associated with a 12-percent reduced odds ratio of testing positive for COVID-19.1. The other half is the adaptive response which learns and then remembers how to fight an infection by designing B . Regardless of if a specific blood type is associated with a greater risk of contracting COVID-19 and developing severe disease, keep in mind that many other factors, such as age or existing health conditions, are likely to play a larger, dominant role in determining personal risk from COVID-19. Symptoms of long COVID. Patient 1 is a 25-year-old man diagnosed with PNH 6 months prior in the setting of hemoglobinuria and had limited disease manifestations not requiring PNH-directed therapy. UNMC researcher Rebekah Gundry, PhD, received a "COVID-19 and Its Cardiovascular Impact Rapid Response Grant" from the American Heart Association in May of 2020. How much virus you were exposed to, your age, plus any of your underlying health conditions also affects the course and severity of the disease. Investigations are also under way into the Johnson & Johnson (J&J) Covid jab amid concerns it may be linked to a similar blood-clotting problem: so far six cases of CVST with low platelets have been reported amid 6.8m doses of the vaccine given in the US, all of which were in women aged between 18 and 48. The risk of death was increased for type AB and decreased for types A and B. The side effects of the three COVID-19 vaccines approved by the FDA for temporary use (Pfizer, Moderna and . These include: chills fatigue fever. Side effects are actually your body's idea - not the vaccine's. When you get a sore arm, fever or fatigue after vaccination, those reactions are your body's way of jumping into action to protect you. Those receiving a bivalent booster and notice side effects within a week of injection are recommended to do the following by CDC officials: Dr. Brown believes that this will not be the last time a new booster vaccine is offered to the American public in fact, experts are projecting that annual vaccines against the spread of COVID-19 may become commonplace soon. Women and younger adults tend to have more side effects than men or older adults do. The relative protective effects of O, Rh-, and O- blood groups were greatest in patients younger than age 70. Notably, she took danicopan throughout her first vaccination and did not experience breakthrough hemolysis. Patient 3 is a 32-year-old woman with a 10-year history of PNH on ravulizumab with her last dose 4 weeks prior to vaccination. What should you have on hand at home? The severity of the COVID-19 disease Recent data suggests that people with blood type A have a significantly higher risk of acquiring COVID-19 than non-A blood types. The most common were fatigue, headache, and new or worsened muscle pain. Patient characteristics and reactions to the COVID-19 vaccines are shown in Table 1. He subsequently was initiated on ravulizumab, a terminal complement inhibitor. "The resulting brownie is the same, though.". Recent data suggest the SARS-CoV-2 spike protein binds heparan sulfate on nucleated cells9 and amplifies the alternative pathway of complement through interference with the binding of CFH, an alternative pathway inhibitor.5 However, CFH primarily binds sialic acid on human erythrocytes,10 and mature erythrocytes express little heparan sulfate.11. I have read that people with certainbloodtypes are more susceptible to contracting COVID-19. Is the COVID-19 thrombotic catastrophe complement-connected? muscle aches. A comprehensive review of studies published in Seminars in Vascular Surgery in September 2021 examined peer-reviewed journal articles published from March 2020 to January 2021. Should you eat before? loss of smell. However, according to the data, a tiny. Studies of the accuracy of serologic tests for anti-SARS-CoV-2 immunoglobulins may assess whether there is variation in antibody titers by ABO and Rh status, the authors noted. But no vaccine is 100% effective, so some people who are fully vaccinated might still become infected with COVID-19 and get sick. And as for your blood type: If you know you have type A or AB blood, this latest research isnt cause for terror, just as having type O blood doesnt mean you can skip the hand sanitizer and other safety measures. Feeling tired. Side effects may even feel like flu and might affect your ability to do daily. Sat, Sun 10 a.m. 4 p.m. It's important to note that individuals will react to these bivalent booster vaccines differently while the most common side effect is pain or swelling at the injection site, many people may feel more severe side effects, and unique combinations of the symptoms listed above. However, the chance of developing severe illness and death after a COVID-19 infection is much higher (2-10%). It's also helpful to know your blood typespecifically the Rh factorduring pregnancy, so your doctor can troubleshoot if the unborn baby has a different Rh factor. Blood clotting is a well-recognized complication of SARS-CoV-2 infection. The data came from critically ill patients at two Vancouver hospitals, where 84 percent of those with blood type A or AB needed intubation and ventilation compared to just 61 percent of those with O or B type blood. In other words, the benefits of the jab far outweigh the risks. However, cases remain very rare: the MHRA noted 79 cases of blood clots with low platelets, including 19 deaths, following more than 20m doses of the AstraZeneca jab, with 44 of the cases and 14 of the deaths related to a rare type of blood clot in the brain called cerebral venous sinus thrombosis (CVST) that occurred with a low platelet count. Adverse reactions appear time-limited and can be managed with supportive care and transfusions as needed. As with all vaccines, side effects may occur after getting the COVID-19 vaccine. A protein called the Rh factor can also be present (+) or absent (-) from the blood. 4. This single nucleotide polymorphism (SNP) is a T at the rs505922 location on the gene. headache, muscle pain, joint pain. muscle pain . What are the most common COVID vaccine side effects? This study provides insight into the mechanism of pharmacodynamic breakthrough precipitated by COVID-19 vaccination in patients with PNH on ravulizumab.